文献-镇痛||A型剧毒的镇痛效果

古文献-镇痛||A型毒伦用于颈迷走神经节阻滞化疗多样近期瘙痒病症

A型伦用于颈迷走神经节阻滞化疗多样近期瘙痒病症：一项随机飞行测试

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本研究借以证明伦通过过后升高皮肤温度更长颈迷走神经阻滞过后时间的假设。笔记进行了一项随机、双盲、对照飞行测试，研究a型伦化疗多样近期瘙痒病症病变颈迷走神经节阻滞的针灸。

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采用75 IU A型伦（伦组）和局部泻药（结果表明），对下肢多样近期瘙痒病症病变进行颈迷走神经节阻滞。

主要结果是1个月后阻滞侧足底与对侧足底的相比较温差变化。

次要结果是3个月后的相比较温差变化以及瘙痒强度变化。

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共有48名旁观者（N=24/组）被随机分配。

伦组的相比较温度上升大于结果表明（并列1.0±1.3℃ vs. 0.1±0.8℃；差异：0.9℃[95%CI：0.3～1.5]；P=0.006）。

可维持至术后3个月，为1.1±0.8 ℃ vs.-0.2±1.2 ℃；P=0.009。

此外，与结果表明相比，伦组在1个月（并列（-2.2±1.0 vs.-1.0±1.6；P=0.003）和3个月（并列（-2.0±1.0 vs.-0.6±1.6；P=0.003）时的瘙痒强度显著减低。

没有人与伦注射涉及的严重不良事件。

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在多样近期瘙痒病症病变中，使用A型伦进行颈迷走神经节阻滞可使患足温度升高3个月，并松弛瘙痒。

Botulinum Toxin Type A for Lumbar Sympathetic GanglionBlock in Complex Regional Pain Syndrome: A Randomized Trial

Background: The present study was designed totest the hypothesis that botulinum toxin would prolong the duration of a lumbarsympathetic block measured through a sustained increase in skin temperature.The authors performed a randomized, double-blind, controlled trial to investigatethe clinical outcome of botulinum toxin type A for lumbar sympathetic ganglionblock in patients with complex regional pain syndrome.

Methods: Lumbar sympathetic ganglion block wasconducted in patients with lower-extremity complex regional pain syndrome using75 IU of botulinum toxin type A (botulinum toxin group) and local anesthetic(control group). The primary outcome was the change in the relative temperaturedifference on the blocked sole compared with the contralateral sole at 1postoperative month. The secondary outcomes were the 3-month changes inrelative temperature differences, as well as the pain intensity changes.

Results: A total of 48 participants (N = 24/group)were randomly assigned. The change in relative temperature increase was higherin the botulinum toxin group than in the control group (1.0°C ± 1.3 vs. 0.1°C ±0.8, respectively; difference: 0.9°C [95% CI, 0.3 to 1.5]; P = 0.006), whichwas maintained at 3 months (1.1°C ± 0.8 vs. -0.2°C ± 1.2, respectively; P =0.009). Moreover, pain intensity was greatly reduced in the botulinum toxingroup compared with the control group at 1 month (-2.2 ± 1.0 vs. -1.0 ± 1.6,respectively; P = 0.003) and 3 months (-2.0 ± 1.0 vs. -0.6 ± 1.6, respectively;P = 0.003). There were no severe adverse events pertinent to botulinum toxininjection.

Conclusions: In patients with complex regionalpain syndrome, lumbar sympathetic ganglion block using botulinum toxin type Aincreased the temperature of the affected foot for 3 months and also reducedthe pain.